The clinical spectrum of infection varies widely from asymptomatic urinary tract infections to severe surgery infections which may lead quickly to a critical sepsis that threatens the life of the individual patient. The clinical presentation may be florid and immediately obvious from the  examinations or, may be subtle and difficult to diagnose even with sophisticated investigations. In any case, a up-to-date antimicrobial guidelines application which is easily accessible for  your doctors is the first step of the chain of antimicrobial stewardship.